An HIV vaccine that has the potential to protect people around the world from the virus has shown promising results. The treatment, which aims to provide immunity against various strains of the virus, produced an anti-HIV immune system response in tests on 393 people, a study in the Lancet found.
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It also protected some monkeys from a virus that is similar to HIV.
But despite advances in treatment for HIV, both a cure and a vaccine for the virus have so far remained elusive.
The drug Prep, or pre-exposure prophylaxis, is effective at preventing HIV infection, but, unlike a vaccine, it needs to be taken regularly, even daily, to prevent the virus from taking hold.
Inventing a vaccine has proved an immense challenge for scientists, in part because there are so many strains of the virus, but also because HIV is adept at mutating to elude attack from our immune systems.
Previous attempts at HIV vaccines have been limited to specific strains of the virus found in certain parts of the world.
But for this “mosaic” vaccine, scientists have developed a treatment made up of pieces of different HIV viruses.
The hope is that it could offer much better protection against the almost unlimited number of HIV strains found across the world.
In a randomised, double-blind, placebo-controlled trial, scientists tested various combinations of the mosaic vaccine in people aged 18 to 50 who did not have HIV and were healthy.
The participants, from the US, Rwanda, Uganda, South Africa, and Thailand, received four vaccinations over the course of 48 weeks.
However, Prof Barouch also cautioned that the findings needed to be interpreted with caution.
Though the vaccine triggered a response in the immune system of the people who took it, it is not clear if this would be enough to fight off the virus and prevent infection.
“The challenges in the development of an HIV vaccine are unprecedented, and the ability to induce HIV-specific immune responses does not necessarily indicate that a vaccine will protect humans from HIV infection,” he added.
‘Promising signs’
Nevertheless, the promising results of the study mean researchers will next test the hiv and std treatment on 2,600 women in southern Africa who are at risk of getting the illness – one of only five vaccines to make it to this stage of so-called efficacy trials.
Only one vaccine has ever shown evidence of protecting against HIV.
Dr Brady added that in the meantime there were already tools that were effective for preventing the disease from spreading, such as contraception and treatments for HIV-positive people that prevent them from passing on the virus.
